The Diabetes Manager

Posts Tagged ‘drugs’

If you wish a cure for cancer, heart disease, Alzheimer, or diabetes, do not count on the academia, the National Institute of Health (NIH), or the biotech/pharmaceutical industry.  With all the cash they need spent on researching these diseases, they need very very little to indicate for it.

In 1971, throughout the State of the Union address, President Nixon declared the war on cancer proposing “an intensive campaign to search out a cure for cancer.”  Since 1971, Americans spent, through taxes, donations, and private R&D, concerning $200 billion in inflation-adjusted dollars.  This money produced 1.56 million papers on cancer. Yet, these days we have a tendency to are no nearer to a cure than we tend to were in 1971.  Why?

Contemplate what Dr. Almog said in his paper: Drug Trade in “depression” (Almog, D. Drug business in “depression”. Med Sci Monit. 2005 Jan;11(1):SR1-4, I would urge you to read his paper, it’s an eye opener on relationship between educational analysis and commercial drug discovery): “When the essential science/biology of disease isn’t accessible, no new medication come to market.” With the billion of greenbacks spent by the NIH on basic science, and therefore the various papers published on the topic, the question is, “Why isn’t the fundamental science/biology of disease obtainable? Individual discoveries in the biology of human disease are cornerstone in new treatments. But, in drug discovery, these basic science/biology discoveries are seemingly unrelated dots. To attach the dots you wish a theory. The Blind Men and therefore the Elephant may be a famous story about six blind men encountering an elephant for the first time. Each man, seizing on the single feature of the animal, which he appeared to own touched first, and being incapable of seeing it whole, loudly maintained his limited opinion on the character of the beast. The elephant was considered a wall, a spear, a snake, a tree, a fan or a rope, depending on whether or not the blind men had initial grasped the creature’s aspect, tusk, trunk, knee, ear or tail. The story epitomizes the matter of the reductionist approach in biology. A recent book Microcompetition with Foreign DNA and the Origin of Chronic Disease, by Hanan Polansky [11], presents an alternative. The book identifies the disruption that causes atherosclerosis, cancer, obesity, osteoarthritis, type II diabetes, alopecia, type I diabetes, multiple sclerosis, asthma, lupus, thyroiditis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, atopic dermatitis, graft versus host disease, and other chronic diseases, and describes the sequence of events that leads from the disruption to the molecular, cellular, and clinical effects.”

What are the implications of the NIH failure?  A decline in the number of latest medicine introduced by pharmaceutical companies. Think about what professor Taylor says in his paper: Fewer new medication from the pharmaceutical industry (Taylor D. Fewer new medicine from the pharmaceutical industry. BMJ. 2003 Feb 22;326(7386):408-9): “In 2002 spending on medicines exceeded $400bn (£248bn; 377bn) worldwide. Optimists within the pharmaceutical business believe that the global marketplace for their products will persist expanding by around 10% a year, with the United States continuing to guide towards higher per capita outlays. Expenditure on research by the pharmaceutical trade is additionally increasing worldwide. It’s now over $45bn a year—twice the add recorded at the start of the 1990s—and projected to rise to $55bn by 2005-6. Issues are growing, however, about the productivity of research being funded by the key pharmaceutical companies. … Empirical proof indicates a crisis in productivity in pharmaceutical research. The amount of medicines introduced worldwide that contain new active ingredients dropped from a median of over 60 a year within the late 1980s to 52 in 1991 and only 31 in 2001. The number of recent active substances undergoing regulatory review is still falling.”

On the one hand, the expenditure on research is increasing.  On the other, the quantity of recent medicine is decreasing.  The professionals decision this example the productivity crisis in drug discovery.

The NIH failed to supply the so abundant required biology of chronic disease as a result of it’s caught within the reductionist mentality.  Dr. Hanan Polansky offers an alternative.  If we need a cure for cancer, heart disease, Alzheimer, or diabetes, we tend to would like to noticeably consider his alternative.

Men – What You Do On A Daily Basis Affects Your Sperm Maturation Method
As a woman is born with every the eggs she’ll still have, men produce sperm on a continual basis. Therefore, what a man does on a daily basis can affect the sperm maturation process.

Smoking, drinking, drugs, stress, poor nutrition and lack of exercise all can contribute to poor sperm quality. And, it was recently discovered, a man’s sperm excellence begins to decline around the age of 25.

There are five vital factors that contribute to overall sperm worth. They include sperm motility, speed, count, concentration and morphology (shape and range).

A weakness in any of these areas be able to affect the chances of conception.

Motility
Sperm motility is a term that describes sperm’s ability to move in an active fashion: inside other words, are the sperm “strong swimmers?” Inside healthy sperm, typically more than 50% are active with over 25% moving forcefully inside one direction. Motility enables the sperm to travel through the cervical canal, into the uterus and the fallopian tubes and, in conclusion, to penetrate the egg.

Speed
The forward movement of sperm called progressive motility, forward advancement or rapid linear improvement. There are also several different ways to classify forward movement.

According to the World Health Organization (1999), in a fit male, greater than 25% of sperm will exhibit progressive motility. It is thought that these are the sperm using the finest chance of successfully fertilizing an egg. Rapid linear advancement showed a better than 60 % gain after four months of cure using acupuncture, herbal medicine and supplements.

Sperm Count
Sperm count refers to the number of sperm inside the fluid that is ejaculated (semen). There are over 40 million sperm in a accepted ejaculate. A complete count below 40 million may possibly indicate decreased fertility.

With the Berkley Center’s unique protocol of acupuncture, herbal medicine and supplements, count increased more than 14 % following four months of treat.

Concentration
Concentration is a measure of the number of sperm cells in a milliliter of semen. Usual concentration is at lowest amount 20 million sperm cells per milliliter of semen.

With the Berkley Center’s unique protocol combining acupuncture, herbal medicine and the appropriate supplements, concentration superior following four months of heal.

Morphology (shape and size)
A healthy sperm cell will have a shape similar to a tadpole. The sperm’s oval head contains the genetic material, the center provides energy and the tail propels the sperm forward.

With the strict criteria put forth by the World Health Organization (1999), studies of Assisted Reproductive Technology programs show lower pregnancy rates using less than 15% natural forms. Furthermore, experts consider that abnormally shaped sperm cannot fertilize an egg.

Subfertility
The term, subfertility, refers to couples that are unable to achieve conception after a year of unprotected intercourse (or 6 months if the female is higher than age 35). It is different from infertility. A subfertile couple merely has lower odds of conceiving during several given month than fertile couples.

Statistics at a glance
Human reproduction is surprisingly inefficient and quite complex — the likelihood of pregnancy within some given month is believed to be simply 25 percent among fertile couples.

1 out of 12 couples have subfertility.

Male-related factors account for 40 percent of subfertility. Woman-related factors account for another 40 percent and a combination of male- and woman-related factors account for about 20 percent.

About 90% of every subfertility can be traced to specific causes that can be treated.

Typical causes of male subfertility
Sperm production problems

Blockages inside the sperm’s delivery system

Injuries to the testicles

Low or high hormone production

Anatomical problems

Varicocele (varicose veins around the testicle)

Past illnesses/infections/various diseases

Certain medications

Sperm quality
Sperm worth is a contributing factor for 40 percent of couples experiencing infertility. There are five significant factors that contribute to sperm worth:

Motility: The ability to move inside an active fashion. Inside well sperm, typically more than 50% are active using higher than 25% moving forcefully inside one direction. Motility is what enables a sperm to travel up the cervical canal, into the uterus and the fallopian tubes and, in conclusion, penetrate the egg.

Speed: Progressive motility. Inside a well male, better than 25% of sperm will exhibit progressive motility. It is thought that these are the sperm using the best chance of successfully fertilizing an egg.

Count: The number of sperm inside the fluid that is ejaculated (semen). There are over 40 million sperm in a accepted ejaculate. A full count beneath 40 million can indicate decreased fertility.

Concentration: A measure of the number of sperm cells inside a milliliter of semen. Natural concentration is at least amount 20 million sperm cells per milliliter of semen.

Morphology: The shape and range of the sperm. A well sperm cell will have a shape similar to a tadpole. The sperm’s oval head contains the genetic material, the center provides power and the tail propels the sperm forward.

Using the strict criteria put forth by the World Health Organization (1999), studies show lower pregnancy rates using less than 15% normal forms. Furthermore, experts believe that abnormally shaped sperm cannot fertilize an egg.

Motility, speed and morphology appear to be the most principal factors to assess the fertilizing capability of sperm. Despite a low sperm count, lots of men using high-worth (viable and highly mobile) sperm might ever be fertile.